Technical Papers and Presentations

Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

On the Simulation of the Metabolism in Mammalian Cells using Homogenization Methods

M. Hanke, and M. Cabauatan-Villanueva
School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden

The simulation of the metabolism in mammalian cells becomes a severe problem if spatial distributions must be taken into account. Especially the cytoplasma has a very complex geometric structure which cannot be handled by standard discretization techniques. In the present paper we propose a homogenization technique for computing effective diffusion constants. This is accomplished by using a ...

Modelling the Coupled Heat and Mass Transfer during Fires in Stored Biomass, Coal and Recycling Deposits

F. Ferrero
Federal Institute for Materials Research and Testing Division II.2, Berlin, Germany

It is known that in big storages of bulk materials the danger of the self-ignition is relevant (long time storages). The Consequences of uncontrolled fires include considerable CO2 emission and economical and human losses to mention a few. The understanding of this phenomena is therefore of great importance.A numerical model can be of great help in understanding such complex phenomena. In this ...

Estimating Cerebral Blood Flow using Electro-mechanical Modeling and Impedance Tomography Measurements

A. Jeremic, and T. Gadkari
McMaster University, Hamilton, ON, Canada

In this paper we propose a coupled electromechanical finite element model which combines the Navier-Stokes Equations of blood flow in an immersed boundary and the resulting deformed geometry with an electromagnetic model, which describes the electric field in the presence of deformation/structure changes caused by the blood flow in arteries.We derive least-squares estimates of the pressure drop ...

Mathematical Modeling of Atheroma Plaque Deformation using COMSOL Multiphysics

N. El Khatib1, S. Genieys1, M. Zine2, and V. Volpert1
1Institut Camille Jordan, Université Claude Bernard, Lyon, France
2Département Maths & Informatique, Ecole Centrale de Lyon, Lyon, France

The development of atherosclerosis leads to the formation of an atheroma plaque which takes place in the artery. This plaque is composed of two parts: a lipid deposit and a fibrous cap. The fibrous cap covers the lipid deposit and isolates it from the blood flow. The blood flow that circulates in the artery modifies the geometry of the atheroma plaque and can cause dangerous effects, such as a ...

Modeling of snRNP Motion in the Nucleoplasm

M. Blaziková[1], J. Malínský[2], D. Stanek[3], and P. Herman[1]
[1]Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic
[2]Institute of Experimental Medicine, Prague, Czech Republic
[3]Institute of Molecular Genetics, Prague, Czech Republic

Small nuclear ribonucleoprotein particles (snRNPs) are essential supramolecular complexes involved in pre-mRNA splicing, the process of post-transcriptional RNA modifications. The particles undergo complex assembly steps inside the cell nucleus in a highly dynamic compartment called the Cajal body. We have previously shown that the free diffusion model does not fully describe the snRNP motion ...

Temperature Excursions at the Pulp-Dentin Junction during the Curing of Light-Activated Dental Restorations

M. Jakubinek[1,2], C. Neill[1], C. Felix[3], R. Price[2,3], M. White[1,2]

[1]Departments of Chemistry and Physics, Dalhousie University, Halifax, NS, Canada
[2]Institute for Research in Materials, Dalhousie University, Halifax, NS, Canada
[3]Department of Dental Clinical Sciences, Dalhousie University, Halifax, NS, Canada

Heat produced during the curing of light-activated dental restorations could damage the dental pulp. Given the prevalence of composite restorations and the importance of avoiding injury to the pulp, efforts should be made to minimize the temperature increase that occurs at the pulp-dentin junction during light-curing. In this investigation we develop and evaluate a COMSOL Multiphysics FEM tooth ...

Multiphysics Modeling of Cellular Arrays Using Periodic Minimal Surfaces – A Drug and Gene Delivery Application

J.I. Rey, A.J. Llewellyn, R.J. Connolly, J.P. Jimenez, A.M. Hoff, and R.A. Gilbert
University of South Florida, Tampa, FL, USA

Minimal surfaces are found in nature from crystalline structures to biological nano and micro structures such as biomembranes, and osseous formations in sea urchin. An application to electrically mediated drug and gene delivery is presented. Periodic level surfaces which approximate minimal surfaces are used to generate a geometric representation of tissue. A method to create such structures ...

Physical and FEM Simulation of Microprobe Insertion into Brain Tissue

A. Eed Olamat, U. Hofmann, B. Pohl, and N. Nkemasong
University of Lübeck, Institute for Signal Processing, Lübeck, Germany

In order to investigate the implantation of microprobes into brain tissue, we developed a finite-element and a physical model to replace real biological tissue for mechanical testing. Penetrating forces of a tungsten indenter into a layered structure was investigated with different indentation speeds. Numerical and physical model are in good correspondence to each other and reproduce measured ...

A Virtual Pharmacokinetic Model Of A Human Eye

L. Murtomäki, and S. Kotha
University of Helsinki, Centre for Drug Research, Helsinki, Finland

Drug therapy of the posterior part of an eye is very challenging. Yet, in USA alone, there are almost 2 million people affected by age related macular degeneration. When designing a strategy for controlled-release drug delivery, it is important to take into account of physiology, absorption, distribution, metabolism, and excretion properties of a drug. Therefore, the aims of this study are: 1) to ...

An Elastic and Hyperelastic Material Model of Joint Cartilage - Calculation of the Pressure Dependent Material Stress in Joint Cartilage

T. Reuter, and M. Hoffmann
fzmb GmbH
Research Centre of Medical Technology and Biotechnology
Bad Langensalza, Germany

In this paper we introduce a elastic and hyperelastic model to describe the pressure dependent material stress in joint cartilage. We used the pressure dependent E-modulus E = f(s) to calculate the material stress. E = f(s) is a degree 4 polynomial . The indentor was pressed 0.4 mm into the tissue. The results show that the maximal stress at the contact zone between indentor and cartilage account ...

Quick Search