Technical Papers and Presentations

Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Computer Simulation Of Haematopoietic Stem Cells Migration Using COMSOL Multiphysics

G. Bencheva
Institute for information and communication technologies, Bulgarian Academy of Sciences, Sofia, Bulgaria

Various haematological diseases, including leukaemia, are characterized by abnormal production of particular blood cells. Two important properties of haematopoietic stem cells (HSCs) are used in their therapy, namely: a) rapid migratory activity and ability to \'\'home\'\' to their niche in the bone marrow; b) high self-renewal and differentiation capacity, responsible for the production and ...

Finite Element Analysis of Equine Tooth Movement Under Masticatory Loading

M. Gardemin[1], M. Lüpke[1], V. Cordes[2], and C. Staszyk[2]
[1]Institute for General Radiology and Medical Physics, University of Veterinary Medicine Hannover, Hannover, Germany
[2]Institute of Anatomy, University of Veterinary Medicine Hannover, Hannover, Germany

Like humans, horses can develop a variety of dental problems. Different equine diseases occur in different areas of the equine cheek tooth or its surrounding tissues. With a realistic simulation of a chewing cycle it can be possible to link mechanical phenomena such as high stress in distinct areas to commonly occurring diseases. According to different angles of the acting chewing force, ...

A Mathematical Tool for Studying Drug Delivery to the Eye in Case of Glaucoma

P. Silva[1], J.A. Ferreira[2], P. de Oliveira[2]
[1]Coimbra Institute of Engineering, CMUC, Coimbra, Portugal
[2]Department of Mathematics University of Coimbra, CMUC, Coimbra, Portugal

The aim of the poster is to present a coupled 2D mathematical model to predict the evolution of drug concentration - in the cornea and in the anterior chamber of the eye - when therapeutic lenses are used (Figure 1). The mathematical model takes into account (i) diffusion processes in several compartments of the eye (therapeutic lens, cornea and anterior chamber); (ii) metabolic consuming ...

3-Dimensional Blood Cooling Model inside a Carotid Bifurcation

R. Sikorski[1], T. Merrill[1]
[1]Rowan University, Glassboro, NJ, USA

Stroke is caused by an interruption of brain blood supply and is one of the leading causes of death and disability. A mild reduction of 2-5°C in tissue temperature through hypothermia has shown reduced tissue infarct size, increased tissue recovery, and positive neurological effects. This paper seeks to predict the outlet blood temperature in the common carotid bifurcation branches. In our ...

Simulation and Experimental Analysis of Drug Release Rates from Magnetic Nanocomposite Spheres

L. Saeeednia[1], H. Mehraein[2], F. Abedin[1], K. Cluff[2], R. Asmatulu[1]
[1]Department of Mechanical Engineering, Wichita State University, Wichita, KS, USA
[2]Department of Bioengineering, Wichita State University, Wichita, KS, USA

Targeted drug delivery systems have been wildly studied in cancer therapy due to the toxicity of most of chemotherapeutic drugs. Nanoparticles can be attached to the small molecules of the drugs and serve as drug carriers to deliver the drug molecules into the area of interest. In this research, polymeric microspheres containing biodegradable poly(D, L-lactide-co-glycolide) (PLGA), magnetic ...

Microwave Exposure System for In Vitro and In Vivo Studies

C. Nadovich[1, 2], W. D. Jemison[2], J. A. Stoute[3], C. Spadafora[4]
[1]Lafayette College, Easton, PA, USA
[2]Clarkson University, Potsdam, NY, USA
[3]Pennsylvania State University, Hershey, PA, USA
[4]INDICASAT AIP, Ciudad del Saber, Panama

A computer controlled microwave exposure system and specialized applicators were constructed for the purpose of facilitating accurate observations of microwave radiation effects on uninfected and infected biological tissue in vitro and in vivo under different electromagnetic modalities and exposure configuration. To address diverse requirements, three different applicators were developed: a ...

On the Influence of Cancellous Bone Structure upon the Electric Field Distribution of Electrostimulative Implants

U. Zimmermann[1], R.Bader[2], U. van Rienen[1]
[1]Institute of General Electrical Engineering, University of Rostock, Rostock, Germany
[2]Department of Orthopaedics, University Medicine Rostock, Rostock, Germany

Since the 1980s, the accelerating effect of electromagnetic fields on bone regeneration is used to treat complicated fractures and bone diseases. At the University of Rostock, an electrostimulative hip revision system is developed, basing on the method of Kraus-Lechner. This method requires an electric fields between 5 and 70 V/m. The bone used for the simulations consisted of two homogenous ...

Microstimulation in The Brain: Does Microdialysis Inuence the Activated Volume of Tissue?

D. Krapohl[1][3], S. Loeffler[2], A. Moser[2], and U.G.Hofmann[1]

[1]Institute for Signalprocessing, University of Luebeck, Lübeck, Germany
[2]Institute for Neurology, University of Luebeck, Lübeck, Germany
[3]Department of Information Technology and Media, Mid Sweden University, Sundsvall, Sweden

Deep Brain Stimulation (DBS) has been established as an effective treatment for Parkinson's disease and other movement disorders. The stimulation is currently administered using tetrode-macroelectrodes that target the Subthalamic Nucleus (STN). This often leads to side effects which bias the surrounding areas, e.g. the speech centre. Targeting a specific brain region can better be achieved with ...

Implementation of Cable Theory of Neurophysiology in COMSOL

G. V. Narayanan
University of Toledo, Toledo, OH, USA

Computational neuroscience seeks to develop mathematical models describing how the nervous system or some part of it carries out certain operations. Unfortunately, realistic models are typically so complex as to preclude a detailed mathematical analysis. Hence, a simplified 1-D cable theory has been developed, and this theory is used in neuroscience to study the behavior of neurons.In this paper, ...

Cavity Sprayer Flow Optimization for Medical Devices Industry

T. Selvam, V.P. Kotte, and M. Marimuthu

HCL Technologies Ltd, Chennai, Tamil Nadu, India

Globally in Otolaryngology industry, Sinusitis is one of the most common diseases related to the nose. Sinusitis is caused when the cilia fail to move the mucus. As a result sinus tissue gets infected that leads to blockage of the sinuses. All the sinusitis can not be cured through drugs and certain require surgery. When a sinus cavity subjected to a nasal endoscopic surgical procedure, one of ...

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